Autophagy in development, cell differentiation, and homeodynamics: from molecular mechanisms to diseases and pathophysiology.

Ioannis P Nezis,Maria I Vaccaro,Rodney J Devenish,Gábor Juhász

doi:10.1155/2014/349623

Abstract

Autophagy in development, cell differentiation, and homeodynamics: from molecular mechanisms to diseases and pathophysiology.

Highlights

Based on the observation that CHMP4B can be coimmunoprecipitated with chromatin, the authors propose that CHMP4B contributes to selective autophagy, here leading to the degradation of micronuclei and other extranuclear chromatin
As a CHMP4B mutation associated with an autosomal dominant form of cataract abolishes the ability of CHMP4B to localize to micronuclei, the autophagic degradation of DNA is implicated in the protection of lens cells from cataract development
These results suggest that the synergistic actions of the two steroid hormones studied accelerate the development of bovine mammary acini, which may be connected in part with the regulation of the molecular machinery involved in autophagy

Summary

Introduction

Editorial Autophagy in Development, Cell Differentiation, and Homeodynamics: From Molecular Mechanisms to Diseases and Pathophysiology The focus of this special issue is to highlight the role of autophagy in cellular homeodynamics, cell differentiation, and development with an outlook to diseases.

Results

Conclusion