Abstract
As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.
Highlights
As a general sensory disorder in human society, hearing loss was a major concern worldwide
As the lipid peroxidation in hair cells (HCs) was investigated through the assessment of the immunoreactivity of 4-HNE, an inverse correlation was established between pexophagy and 4-HNE, which suggested that pejvakin-mediated pexophagy plays a critical role in redox homeostasis and HC protection against noise-induced damage [82]
Autophagy is involved in a variety of signaling pathways and plays a major role in the development and protection of HCs
Summary
As a general sensory disorder in human society, hearing loss was a major concern worldwide. During a variety of pathological and physiological states, the activation of autophagy seems beneficial, as it removes damaged organelles or defends microbial infection and is important in various diseases related to metabolism or neurodegeneration [7]. Autophagy suppresses necroptosis and PARP-mediated cell death under cellular stress conditions. Several studies revealed the link between autophagy and hearing protection and proved that the upregulation of autophagy might contribute to the alleviation of morphological damage in the inner ear [6, 10]. We aimed to establish the correlation between autophagy and hair cells (HCs), determined the effect of autophagy in hearing loss, and further discussed whether autophagy could serve as a potential measure in the protection of HCs
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