Abstract
The effects of cyclohexylamine have been studied in isolated tissues. It caused contraction of the smooth muscle of the guinea pig ileum by activation of cholinergic atropine-sensitive receptors but not strychnine-sensitive presynaptic receptors. The contractions of the ileum were not enhanced by physostigmine. It also contracted the rat urinary bladder by activation of hexamethonium-sensitive receptors. Contraction of rat vas deferens could be blocked by either phenoxybenzamine, phentolamine, or atropine, indicating activation of alpha adrenergic receptors as well as cholinergic receptors of that tissue. Contraction of a skeletal muscle, the frog rectus abdominis, could not be blocked by d-tubocurare demonstrating a noncholinergic stimulation by cyclohexylamine. This action on skeletal muscle occurred in a calcium-free medium and after muscle depolarization with excess potassium. Although the contraction could be reversed in part, by addition of acid to the medium, it was not due entirely to a pH effect of cyclohexylamine.
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