Abstract
Recent studies have demonstrated that autonomic regulation therapy (ART) via chronic open-loop, intermittent vagus nerve stimulation (VNS) may have cardioprotective effects in animals and humans with heart failure and cardiac arrhythmias. When ART is first activated, VNS intensity is constrained by a central expiratory reflex that triggers mild coughing that coincides with VNS. In response to chronic, continuously-cyclic VNS, reflex adaptation occurs, and the tolerance zone boundary (TZB) increases over several weeks.
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