Autonomic modulation of qt intervals in post-myocardial infarction patients with and without ventricular fibrillation

Abstract

The autonomic nervous system plays an important role in the genesis of sudden cardiac death. The aim of this study was to evaluate spatial autonomic QT interval modulation at the myocardial level. Circadian patterns of QT intervals and heart rate variability (HRV) components and their hourly linear correlations were determined by Holter recordings in 15 healthy subjects (controls), in 15 post-myocardial infarction (MI) patients resuscitated from ventricular fibrillation (VF) (VF group), and in 15 matched infarction patients without a history of arrhythmia events (MI group). QT intervals were measured in modified leads V 1 and V 5 individually at same stable heart rates during each hour and related to hourly measures of HRV. Controls had highly significant correlations between QT intervals and the high-frequency component of HRV (parasympathetic modulation), and between QT intervals and low- to high-frequency ratio (sympathetic modulation) uniformly in both leads (r from 0.62 to 0.81, p <0.001). The MI group had impaired sympathetic modulation in V 5 (r = 0.34, p = NS), but had uniform and exaggerated sensitivity to parasympathetic modulation. In the VF group the QT difference between V 1 and V 5 leads correlated with parasympathetic modulation (r = 0.401, p <0.05) and sympathetic modulation (r = 0.446, p <0.05). Thus, normal subjects exhibit spatially uniform autonomic QT modulation. Myocardial damage can result in abolished, exaggerated, or regionally discordant QT modulation, and this may generate arrhythmic vulnerability.