Abstract
SummaryObjectivesThe pathogenesis of primary Raynaud’s phenomenon (RP) seems to be multifactorial and autonomic nervous dysfunction is one factor. Heart rate variability (HRV) is one of the most reliable parameters to demonstrate autonomic dysfunction. Our aim was to evaluate the time-domain HRV in patients with primary RP.MethodsA time analysis of HRV was performed in patients with primary RP and age- and gender-matched healthy controls. The results of the study and control group were compared.ResultsThirty patients with primary RP [all men, median (IQR) age: 21 (2) years) and 31 age- and gender-matched healthy controls (median (IQR): 21(3) years) were enrolled in the study. We found a statistically significant difference between the primary RP patients and control subjects in terms of time-domain HRV parameters (p < 0.05 for all).ConclusionOur study showed the presence of autonomic nervous dysfunction of heart function in patients with primary RP.
Highlights
Our study showed the presence of autonomic nervous dysfunction of heart function in patients with primary Raynaud’s phenomenon (RP)
Since sympathovagal balance is affected in favour of sympathetic activation in patients with primary RP, in this study, we evaluated the baseline function of the autonomic nervous system assessed by 24-hour Heart rate variability (HRV) analysis in patients with primary RP
Statistical analysis of the HRV analyses showed a significant decrease in time-domain variables of Standard deviation of all R–R intervals (SDNN), RMSDD, NN50 count, PNN50 and SDNN index between the two groups (p < 0.05 for all) (Table 2)
Summary
The pathogenesis of primary Raynaud’s phenomenon (RP) seems to be multifactorial and autonomic nervous dysfunction is one factor. Heart rate variability (HRV) is one of the most reliable parameters to demonstrate autonomic dysfunction. Our aim was to evaluate the time-domain HRV in patients with primary RP. Methods: A time analysis of HRV was performed in patients with primary RP and age- and gender-matched healthy controls. Results: Thirty patients with primary RP [all men, median (IQR) age: 21 (2) years) and 31 age- and gender-matched healthy controls (median (IQR): 21(3) years) were enrolled in the study. We found a statistically significant difference between the primary RP patients and control subjects in terms of time-domain HRV parameters (p < 0.05 for all).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
