Abstract
Abstract Objetive: To evaluate the association between sympathetic nervous system activity and blood pressure variability with central serous chorioretinopathy (CSC). Methods: We performed an individual, observational, and cross-sectional study involving 11 patients with CSC and 16 healthy individuals in similar age range. Participants underwent spectral power analysis of heart rate variability (HRV) at the Hypertension Department of Heart Institute at the University of Sao Paulo. Results: We demonstrated sympathetic activity predominance in CSC group and found that the LF (low frequency) of heart rate variability was significantly higher in this group (p = 0.04). when compared to control group. The CSC group's mean LF / HF (high frequency) ratio was higher than the control group but was not statistically significant (p = 0.2). Blood pressure variability was higher in CSC patients than in normal patients (p = 0.055), whereas heart rate variability was lower in these patients when compared to normal patients, although no statistical significance was found (p = 0.2). Spontaneous baroreflex function was significantly reduced in patients with CSC when compared to healthy individuals (p = 0.04). Conclusion: Autonomic dysfunction and a predominance of sympathetic modulation were observed in CSC patients.
Highlights
Central serous chorioretinopathy (CSC) is a condition characterized by serous detachment of the neurosensory retina and can be associated with retinal pigment epithelium (RPE) detachment
Because stress response and choroidal circulation are regulated by the autonomic nervous system (ANS), it has been suggested that ANS stimulation is associated to choroidal hyperpermeability and consequent onset of this disease
The aim of this study is to evaluate the association between sympathetic nervous system activity and CSC
Summary
Central serous chorioretinopathy (CSC) is a condition characterized by serous detachment of the neurosensory retina and can be associated with retinal pigment epithelium (RPE) detachment. This condition is usually restricted to the macular area and caused by the leakage of fluids through RPE into the subretinal space due to increased choroidal permeability.[1]. There are only a few studies showing this association. In this context, the aim of this study is to evaluate the association between sympathetic nervous system activity and CSC
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