Abstract

Arousals may occur during sleep spontaneously or following respiratory disorders, and are recognised as cortical and/or autonomic activation. Autonomic nervous system (ANS) activity may differ between Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS). We analysed nocturnal cardiorespiratory (Somnocheck Micro, Weinmann) and polysomnography (PSG) recordings (SomnoLab2, Weinmann), simultaneously performed in ventilated patients, 16 affected by DMD and 16 by ALS. Our aims were to evaluate relationships between: 1) autonomic arousals (AA), detected as pulse wave amplitude variations, and cortical arousals (CA); 2) respiratory AA and disordered breathing events; 3) occurrence of AA and ANS activity, assessed with the analysis of heart rate (HR) variability. Respiratory events and AA were automatically detected by the cardiorespiratory monitor. CA were visually detected on the PSG. HR variability was analysed on the PSG ECG signal by a commercial software (Kubios HRV). In DMD, AA exceeded CA rate (40.4±10 vs 19.7±5 p

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