Abstract
Stressful life events are an important cause of psychopathology. Humans exposed to aversive or stressful experiences show considerable inter-individual heterogeneity in their responses. However, the majority does not develop stress-related psychiatric disorders. The dynamic processes encompassing positive and functional adaptation in the face of significant adversity have been broadly defined as resilience. Traditionally, the assessment of resilience has been confined to self-report measures, both within the general community and putative high-risk populations. Although this approach has value, it is highly susceptible to subjective bias and may not capture the dynamic nature of resilience, as underlying construct. Recognizing the obvious benefits of more objective measures of resilience, research in the field has just started investigating the predictive value of several potential biological markers. This review provides an overview of theoretical views and empirical evidence suggesting that individual differences in heart rate variability (HRV), a surrogate index of resting cardiac vagal outflow, may underlie different levels of resilience toward the development of stress-related psychiatric disorders. Following this line of thought, recent studies describing associations between regional brain morphometric characteristics and resting state vagally-mediated HRV are summarized. Existing studies suggest that the structural morphology of the anterior cingulated cortex (ACC), particularly its cortical thickness, is implicated in the expression of individual differences in HRV. These findings are discussed in light of emerging structural neuroimaging research, linking morphological characteristics of the ACC to psychological traits ascribed to a high-resilient profile and abnormal structural integrity of the ACC to the psychophysiological expression of stress-related mental health consequences. We conclude that a multidisciplinary approach integrating brain structural imaging with HRV monitoring could offer novel perspectives about brain-body pathways in resilience and adaptation to psychological stress.
Highlights
Psychological stress is common in our fast-paced society and strongly influences our mental and physical well-being
This review aimed to integrate theoretical views and empirical evidence suggesting that individual differences in resting state vagallymediated heart rate variability (HRV) may underlie differential resilience to the development of stress-related psychological disorders
Positive associations between morphological characteristics of the anterior cingulated cortex (ACC), its cortical thickness, and individual differences in vagally-mediated HRV have been reported in several independent studies
Summary
Luca Carnevali 1,2*, Julian Koenig 3,4, Andrea Sgoifo 2 and Cristina Ottaviani 1,5. Reviewed by: Beverley Greenwood-VanMeerveld, University of Oklahoma Health Sciences Center, United States. Specialty section: This article was submitted to Autonomic Neuroscience, a section of the journal
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