Abstract
Multidimensional chromatography using on-line, coupled, micro-column size exclusion chromatography and reversed-phase high performance liquid chromatography, has been successfully implemented for the quantitative determination of photoinitiator concentrations in photosensitive, interlayer dielectric resin formulations. The actual formulation consists of the prepolymer, aromatic solvent, antioxidant, and a variety of bis-azide photocrosslinkers. This paper describes the development of an automated system for Micro SEC-LC, as well as accuracy and precision data for the photoinitiator analysis. The technology is very effective for the analysis of small molecules (e.g. additives) in polymer products, and as such can have wide ranging applicability to other polymer and complex products. The use of microcolumns in the first dimension allows the introduction of the complete fraction containing the components of interest into a reversed-phase second dimension without deterioration of the separation when using a very strong mobile phase such as THF.
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