Automating ADC Manufacturing with Electricity

Abstract

Combining the specificity and stability of antibodies with the potency of small molecules has always been at the core of the antibody-drug conjugate (ADC) field. The technological challenge to this therapeutic approach is in bringing two disparate molecules in union with one another. Once this was achieved, the next technological hurdle was, in essence, automation. Early versions of an ADC were the product of technical skill which also required trial and error. Bioconjugation experts investigated many combinations of antibodies, small molecule drugs, conditions, and reaction times to produce stable and efficacious final drugs. This work serves as a technical knowledge base from which to convert new antibodies into ADCs. Even with compendium textbooks like Bioconjugate Techniques, trial and error is still required especially to manufacture an ADC at clinical scale.