Automatic Sensory Discrimination Deficits in the Prodrome and First-Episode of Psychosis

Abstract

Event Abstract Back to Event Automatic Sensory Discrimination Deficits in the Prodrome and First-Episode of Psychosis Kristin S. Cadenhead1*, C. Jahchan1, D. L. Braff1 and G. Light1 1 Department of Psychiatry, University of California, United States BACKGROUND Schizophrenia is a neurodevelopmental disorder with evidence of progressive changes in the early phase of illness. Earlier identification and a better understanding of the mechanism by which psychosis evolves can lead to preventive, more personalized treatment. Deficits in automatic sensory discrimination as indexed by mismatch negativity (MMN) are well documented in chronic schizophrenia patients. The majority of previous studies in the early stages of illness, however, failed to detect MMN impairments to either pitch or duration deviants. METHODS 12 individuals at-risk for psychosis (AR), 23 patients with first-episode psychosis (FE), and 40 normal comparison subjects (NC) underwent duration-deviant MMN testing (1000 Hz tones, standards: 50 msec, P=0.90; deviants: 100 msec, P=0.10). RESULTS Group differences were present in the amplitude of the MMN at fronto-central electrodes (Fz p=.008, F3 p=.007, F4 p=.013, Cz p=.012, C3 p=.027, C4 p=.118). The AR group's MMN amplitudes were intermediate between those of the NC group and the FE group, but those differences did not reach statistical significance (effect sizes .21-.35). CONCLUSIONS Robust duration-deviant MMN deficits were observed in first-episode psychosis patients. Individuals at risk for developing schizophrenia had small reductions relative to normal subjects that likely reflect the fact that less than ½ will go on to develop a psychotic illness. MMN may represent an important disease marker that can help to predict who is at greatest risk of psychotic illness. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Symposium 1: MMN as a potential endophenotype in schizophrenia Citation: Cadenhead KS, Jahchan C, Braff DL and Light G (2009). Automatic Sensory Discrimination Deficits in the Prodrome and First-Episode of Psychosis. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.033 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Mar 2009; Published Online: 20 Mar 2009. * Correspondence: Kristin S Cadenhead, Department of Psychiatry, University of California, San Diego, United States, kcadenhead@ucsd.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kristin S Cadenhead C. Jahchan D. L Braff G. Light Google Kristin S Cadenhead C. Jahchan D. L Braff G. Light Google Scholar Kristin S Cadenhead C. Jahchan D. L Braff G. Light PubMed Kristin S Cadenhead C. Jahchan D. L Braff G. Light Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.