Abstract

Segmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach for segmenting retinal layers in Spectral Domain Optical Coherence Tomography images using graph theory and dynamic programming. Results show that this method accurately segments eight retinal layer boundaries in normal adult eyes more closely to an expert grader as compared to a second expert grader.

Highlights

  • Accurate detection of anatomical and pathological structures in Spectral Domain Optical Coherence Tomography (SDOCT) images is critical for the diagnosis and study of ocular diseases [1,2]

  • While the proposed technique can be generalized for segmenting any layered structure in images of any imaging modality, we focus on the segmentation of retinal layers in SDOCT images

  • Knowledge of these layer boundary positions allows for retinal layer thickness calculations, which are imperative for the study and detection of ocular diseases

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Summary

Introduction

Accurate detection of anatomical and pathological structures in Spectral Domain Optical Coherence Tomography (SDOCT) images is critical for the diagnosis and study of ocular diseases [1,2]. Knowledge of these layer boundary positions allows for retinal layer thickness calculations, which are imperative for the study and detection of ocular diseases.

A generalized layer segmentation algorithm
Graph representation and weight calculation
Automatic endpoint initialization
Search region limitation
Finding the minimum-weighted path
Feedback and iteration
Implementation for segmenting eight retinal layer boundaries
Image flattening
Calculate graph weights
Segmenting the vitreous-NFL and the IS-OS
Search region limitation using connectivity-based segmentation
Vessel detection
Segmenting the NFL-GCL
Detecting the fovea and segmenting the IPL to ONL layer boundaries
Segmenting the IS to choroid layer boundaries
Automated versus manual segmentation study
29 B-scans
Other segmentation results
Conclusion
Full Text
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