Abstract

Automatic liver tumor segmentation would have a big impact on liver therapy planning procedures and follow-up assessment, thanks to standardization and incorporation of full volumetric information. In this work, we develop a fully automatic method for liver tumor segmentation in CT images based on a 2D fully convolutional neural network with an object-based postprocessing step. We describe our experiments on the LiTS challenge training data set and evaluate segmentation and detection performance. Our proposed design cascading two models working on voxel- and object-level allowed for a significant reduction of false positive findings by 85% when compared with the raw neural network output. In comparison with the human performance, our approach achieves a similar segmentation quality for detected tumors (mean Dice 0.69 vs. 0.72), but is inferior in the detection performance (recall 63% vs. 92%). Finally, we describe how we participated in the LiTS challenge and achieved state-of-the-art performance.

Highlights

  • According to the World Health Organization, liver cancer was the second most common cause of cancer-induced deaths in 2015

  • The medical-technical radiology assistant (MTRA) missed 11 of the Liver Tumor Segmentation (LiTS) lesions and found 78 additional ones, which accounts for 0.92 recall and 2.6 false positives (FP)/case

  • There were two cases, where MTRA segmentation got 0 dice/case when compared with the LiTS reference: (i) a tumor was found in a case with no tumors, Fig. 3c, (ii) none of reference tumors were found

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Summary

Introduction

According to the World Health Organization, liver cancer was the second most common cause of cancer-induced deaths in 2015. Liver tumors show a high variability in their shape, appearance and localization. They can be either hypodense (appearing darker than the surrounding healthy liver parenchyma) or hyperdense (appearing brighter), and can have a rim due to the contrast agent accumulation, calcification or necrosis[3]. The individual appearance depends on lesion type, state, imaging (equipment, settings, contrast method and timing), and can vary substantially from patient to patient. This high variability makes liver lesion segmentation a challenging task in practice. In 2008, the MICCAI 3D Liver Tumor Segmentation Challenge[4] was organized where both manual and automatic methods were accepted. The final output was refined using a 3D conditional random field

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