Automatic Grading System for Diabetic Retinopathy Diagnosis Using Deep Learning Artificial Intelligence Software

Abstract

ABSTRACT Purposes: To describe the development and validation of an artificial intelligence–based, deep learning algorithm (DeepDR) for the detection of diabetic retinopathy (DR) in retinal fundus photographs. Methods: Five hundred fundus images, which had detailed labelling of DR lesions, were transmitted to be analysed, including localization of the optic disk and macular, vessel segmentation, detection of lesions, and grading of DR. The multi-level iterative method of convolutional neural network and the strategy of enhanced learning were used to improve the accuracy of the system (DeepDR) for grading DR. Three public data sets were used to further train the software. The final grading results were tested based on the fundus images provided by the hospitals. Results: For 6788 fundus images (both macular and disc centred) of two Hospital Eye Center, the detection of microaneurysm, haemorrhage and hard exudates had an accuracy of 99.7%, 98.4% and 98.1%, respectively. The current algorithm accuracy was 0.96. Another 20,000 fundus images from community screening were selected, and 7593 photos of poor quality were excluded according to quality standards. Accuracy for accurate staging of fundus photos: accuracy was 0.9179. The sensitivity, specificity and area under the curve (AUC) were 80.58%, 95.77% and 0.9327, respectively. Conclusions: This artificial intelligence–based DeepDR can be used with high accuracy for the detection of DR in retinal images. This technology offers the potential to increase the efficiency and accessibility of DR screening programs.