Abstract
The preparation of an automatic extractor using ODS-minicolumn (25mm × 9mm i.d.) for analysis of drugs of abuse in biological fluids and its application are described. The auto-extraction method consists of the sequential operations, adsorption-washing (clean up)-elution(collection of the analyte) and regeneration of column, which continue repeatedly. Recoveries of drugs from spiked plasma and urine samples with the auto-extractor were almost quantitative at the optimum pH and much better than that of the conventional extraction with ether. Reproducibility of the auto-extraction was fairly good and the relative standard deviations of 10 measurements for methamphetamine, THC, morphine, cocaine and methaqualone in urine and plasma were from 0.55% to 4.35%. The simultaneous extractions of methamphetamine, THC, tranquilizers and their metabolites in urine with the autoextractor are presented as applications.
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