Automatic discrimination of actinic keratoses from clinical photographs

Abstract

Background and ObjectiveActinic keratoses (AK) are common premalignant skin lesions that can progress to invasive skin squamous cell carcinoma (sSCC). The subtle accumulation of multiple AK in aging individuals increases the risk of sSCC development, and this underscores the need for efficient treatment and patient follow-up. Our objectives were to develop a method based on color texture analysis of standard clinical photographs for the discrimination of AK from healthy skin and subsequently to test the developed approach in the quantification of field-directed treatment interventions. MethodsAK and healthy skin in clinical photographs of 22 patients were demarcated by experts and regions of interest (ROIs) of 50 × 50 pixels were cropped. The data set comprised 6010 and 13915 ROIs from AK and healthy skin, respectively. Color texture features were extracted using local binary patterns (LBP) or texton frequency histograms and evaluated employing a support vector machine (SVM) classifier. Classifier evaluation was performed using a leave-one-patient-out scheme in RGB, YIQ and CIE-Lab color spaces. The best configuration of the SVM model was tested using 157 AK and 216 healthy skin rectangular regions of arbitrary size. AK treatment outcome was evaluated in an additional group of eight patients with 32 skin lesions. ResultsThe best configuration of the discrimination model was achieved by employing LBP color texture descriptors estimated from the Y and I components of the YIQ color space. The sensitivity and specificity of the SVM model were 80.1% and 81.1% at ROI level and 89.8% and 91.7% at region level, respectively. Based on the classifier results the quantitative AK reduction was 83.6%. ConclusionsIt is important that patients with AK seek evaluation for treatment to reduce the risk of disease progression. Efficient patient follow-up and treatment evaluation require cost-effective and easy to use approaches. The proposed SVM discrimination model based on LBP color texture analysis renders clinical photography a practical, widely available and cost-effective tool for the evaluation of AK burden and treatment efficacy.