Abstract
Bioresorbable vascular scaffolds (BVS) have gained significant interest in both the technical and clinical communities as a possible alternative to metallic stents. For accurate BVS analysis, intravascular optical coherence tomography (IVOCT) is currently the most suitable imaging technique due to its high resolution and the translucency of polymeric BVS struts for near infrared light. However, given the large number of struts in an IVOCT pullback run, quantitative analysis is only feasible when struts are detected automatically. In this paper, we present an automated method to detect and measure BVS struts based on their black cores in IVOCT images. Validated using 3 baseline and 3 follow-up data sets, the method detected 93.7% of 4691 BVS struts correctly with 1.8% false positives. In total, the Dice's coefficient for BVS strut areas was 0.84. It concludes that this method can detect BVS struts accurately and robustly for tissue coverage measurement, malapposition detection, strut distribution analysis or 3D scaffold reconstruction.
Highlights
In coronary artery disease (CAD), plaques build up in the vessels and obstruct the oxygenrich blood supply to the heart muscle, which can cause angina or eventually a heart attack
The first introduced stent was the bare metal stent (BMS), with a known risk of neointimal hyperplasia (NIH) which re-narrows of the vessel lumen [2]
We present an automated method to detect Bioresorbable vascular scaffolds (BVS) struts and to measure their black core areas in intravascular optical coherence tomography (IVOCT) pullback runs
Summary
In coronary artery disease (CAD), plaques build up in the vessels and obstruct the oxygenrich blood supply to the heart muscle, which can cause angina or eventually a heart attack. The drug-eluting stent (DES) emerged as an alternative to the BMS. It can alleviate NIH significantly, but later, multiple risk factors became evident, such as late stent thrombosis and late acquired malapposition [3, 4]. A new concept of the temporary stent or scaffold was proposed. Such a device is designed to offer temporary radial strength to avoid the acute vessel closure as a consequence of the acute vessel recoil, and at a later stage, it will be fully absorbed, leading to restoration
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