Automatic classification of ICA components from infant EEG using MARA

I Marriott Haresign,E Phillips,M Whitehorn,V Noreika,E.J.H Jones,V Leong,S.V Wass

doi:10.1016/j.dcn.2021.101024

Abstract

Automated systems for identifying and removing non-neural ICA components are growing in popularity among EEG researchers of adult populations. Infant EEG data differs in many ways from adult EEG data, but there exists almost no specific system for automated classification of source components from paediatric populations. Here, we adapt one of the most popular systems for adult ICA component classification for use with infant EEG data. Our adapted classifier significantly outperformed the original adult classifier on samples of naturalistic free play EEG data recorded from 10 to 12-month-old infants, achieving agreement rates with the manual classification of over 75% across two validation studies (n = 44, n = 25). Additionally, we examined both classifiers’ ability to remove stereotyped ocular artifact from a basic visual processing ERP dataset compared to manual ICA data cleaning. Here, the new classifier performed on level with expert manual cleaning and was again significantly better than the adult classifier at removing artifact whilst retaining a greater amount of genuine neural signal operationalised through comparing ERP activations in time and space. Our new system (iMARA) offers developmental EEG researchers a flexible tool for automatic identification and removal of artifactual ICA components.

Highlights

The use of EEG in developmental cognitive neuroscience has led to a rich understanding of how the brain develops throughout early life
Third, we examined event-related potential (ERP) data generated using the different systems to examine in greater detail their ability to remove specific types of artifact
Our analysis indicated that all methods of Independent components analysis (ICA) cleaning removed statistically similar amounts of frontal pole activity from the raw data, but that neither the data cleaned manually nor iMARA removed all of the frontal pole activity associated with the eye movement artifact

Summary

Introduction

The use of EEG in developmental cognitive neuroscience has led to a rich understanding of how the brain develops throughout early life. EEG has provided insights from birth into the development of skills such as face processing (e.g., Farroni et al, 2002), attention (e.g., Xie et al, 2018), memory (e.g., Jones et al, 2020) and social interaction (e.g., Wass et al, 2018). It has been pivotal in identifying risk factors associated with developmental disorders (e.g., Orekhova et al, 2014) and later emerging psychopathology (e.g., Jones and Johnson, 2017).

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