Abstract
Three-dimensional acoustic tissue models (3DATMs) can be used as computational tools for ultrasonic imaging algorithm development and analysis. 3DATMs are automatically constructed from digitized light microscope images of consecutive H&E-stained histologic tissue sections. Construction necessitated contrast equalization, registration, and interpolation of missing sections. The registered (with interpolated) sections yield a 3D histologic volume (3DHV). Acoustic properties are then assigned to each tissue constituent of the 3DHV to obtain the 3DATM. A tissue characterization technique was developed to obtain scatterer parameter estimates (size and acoustic concentration) from a 3D impedance map (3DZM) deduced from a 3DHV by assigning acoustic impedance values. 3DZMs were constructed for a rat fibroadenoma (FA), a mouse mammary tumor (MMT) and a mouse sarcoma (EHS). From these 3 3DZMs estimates, effective scatterer diameters of 91 μm, 31.5 μm, and 34.5 μm, respectively, were determined. Independent ultrasonic measurements yielded average scatterer diameters of 105 μm, 30 μm, and 33 μm, respectively. The 3DZM estimation scheme showed results similar to those obtained by the ultrasonic measurements. 3DATMs may therefore be a useful tool for quantifying ultrasonic tissue properties. [Work supported by the University of Illinois Research Board.]
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