Abstract
This article describes a method by which about a hundred mCi of different radiopharmaceuticals (imipramine, chlorpromazine, nicotine or methionine) may be prepared in 30–35 min with no irradiation risk to the operators. All operations (preparation of precursor, methylation of the monodesmethyl derivative, purification and sterilisation of the end product) are carried out in a closed shielded hood. The passage of fluids from one reaction tube to another through flexible teflon capillaries is controlled by electrovalves and purification is achieved by HPLC. The end products are chromatographically pure, sterile and apyrogenic. Their specific radioactivity at the time of use averages 500 mCi/μmol (maximum 1.0 Ci/μmol).
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