Automated segmentation of leukocyte from hematological images\u2014a study using various CNN schemes

Abstract

Medical images play a fundamental role in disease screening, and automated evaluation of these images is widely preferred in hospitals. Recently, Convolutional Neural Network (CNN) supported medical data assessment is widely adopted to inspect a set of medical imaging modalities. Extraction of the leukocyte section from a thin blood smear image is one of the essential procedures during the preliminary disease screening process. The conventional segmentation needs complex/hybrid procedures to extract the necessary section and the results achieved with conventional methods sometime tender poor results. Hence, this research aims to implement the CNN-assisted image segmentation scheme to extract the leukocyte section from the RGB scaled hematological images. The proposed work employs various CNN-based segmentation schemes, such as SegNet, U-Net, and VGG-UNet. We used the images from the Leukocyte Images for Segmentation and Classification (LISC) database. In this work, five classes of the leukocytes are considered, and each CNN segmentation scheme is separately implemented and evaluated with the ground-truth image. The experimental outcome of the proposed work confirms that the overall results accomplished with the VGG-UNet are better (Jaccard-Index = 91.5124%, Dice-Coefficient = 94.4080%, and Accuracy = 97.7316%) than those of the SegNet and U-Net schemes Finally, the merit of the proposed scheme is also confirmed using other similar image datasets, such as Blood Cell Count and Detection (BCCD) database and ALL-IDB2. The attained result confirms that the proposed scheme works well on hematological images and offers better performance measure values.