Automated lateralization of temporal lobe epilepsy with cross frequency coupling using magnetoencephalography

Abstract

ObjectiveLateralization of seizure focus in temporal lobe epilepsy (TLE) is a prime step in pre-surgical evaluation requiring prolonged seizure monitoring using video EEG and manual inspection of recordings. This study uses phase amplitude coupling (PAC) in resting state magnetoencephalography to automatically lateralize TLE focus. MethodsFifty-four patients with drug resistant TLE and 21 healthy controls who underwent MEG were considered for the study. Classification was carried out for PAC calculated for source transformed resting state of controls vs left TLE (LTLE)/right TLE (RTLE) and LTLE vs RTLE between beta, low-gamma and high-gamma as high frequency (HF) bands and low frequency (LF) 1–13 Hz, with decision tree (DT), support vector machines (SVM) and naïve Bayes with feature selection by chi-square test. Further, lateralization classification was also calculated with LF sub-bands (delta, theta, alpha). ResultsPAC was higher in the TLE compared to controls. LTLE and RTLE showed differences in low gamma-alpha and high gamma-delta coupling (p < 0.05). Accuracy was highest with SVM between controls and LTLE in the low gamma-LF (92.92%, AUC-1), between controls and RTLE in DT and SVM (93.54%, AUC-0.97, 1) in the low gamma-LF band and in low gamma-delta band in SVM (92.04%, AUC-1) between LTLE and RTLE. ConclusionsPAC shows distinct patterns of coupling in each subject group. Feature selection showed involvement of major network hubs and resting state networks. SVM showed best classification potential in the low gamma band. SignificancePAC in resting state MEG can supplement pre-surgical evaluation in drug resistant TLE.