Abstract
A new diffusion cell design is reported for conducting in vitro dermal absorption tests. This disposable cell was inexpensive to construct and reduces the risk of inter-test cross-contamination. A disadvantage was that the polymer material used adsorbed the lipophilic test compound, 14C-nonyl phenol. Data is presented for absorption of tritiated water and 14C-nonyl phenol in a dialysis membrane model, SnakeskinTM and for tritiated water in human skin (Kp = 6.3 ± 0.78 cm/h × 10−3). Further testing is needed to evaluate the capacity of the ‘Dispo’ cell for use with lipophilic test chemicals.
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