Abstract
Total-vaporization solid-phase microextraction (TV-SPME) with on-fiber derivatization can simplify sample preparation for a variety of analytes compared to traditional methods for gas chromatography-mass spectrometry (GC-MS) analysis. Microgram quantities of drugs such as amphetamine, ephedrine, methamphetamine, 2C-I, 25I-NBOMe, 25I-NBOH, and gamma-hydroxybutyric acid (GHB) were analyzed in solution using TV-SPME. Derivatization can allow for analytes that cannot normally be detected by GC-MS to be identified and can improve chromatographic performance and sensitivity. TV-SPME also simplifies the process of derivatization by allowing it to take place on the fiber, which can be automated using a robotic autosampler. This technique also displays great versatility in decreasing sample preparation for a variety of sample matrices.
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