Automated delineation of orbital abscess depicted on CT scan using deep learning.

Abstract

To develop and validate a deep learning algorithm to automatically detect and segment an orbital abscess depicted on computed tomography (CT). We retrospectively collected orbital CT scans acquired on 67 pediatric subjects with a confirmed orbital abscess in the setting of infectious orbital cellulitis. A context-aware convolutional neural network (CA-CNN) was developed and trained to automatically segment orbital abscess. To reduce the requirement for a large dataset, transfer learning was used by leveraging a pre-trained model for CT-based lung segmentation. An ophthalmologist manually delineated orbital abscesses depicted on the CT images. The classical U-Net and the CA-CNN models with and without transfer learning were trained and tested on the collected dataset using the 10-fold cross-validation method. Dice coefficient, Jaccard index, and Hausdorff distance were used as performance metrics to assess the agreement between the computerized and manual segmentations. The context-aware U-Net with transfer learning achieved an average Dice coefficient and Jaccard index of 0.78±0.12 and 0.65±0.13, which were consistently higher than the classical U-Net or the context-aware U-Net without transfer learning (P<0.01). The average differences of the abscess between the computerized results and the experts in terms of volume and Hausdorff distance were 0.10±0.11mL and 1.94±1.21mm, respectively. The context-aware U-Net detected all orbital abscess without false positives. The deep learning solution demonstrated promising performance in detecting and segmenting orbital abscesses on CT images in strong agreement with a human observer.