Automated Computer Aided Diagnosis Using Altered Multi-Phase Level Sets in Application to Categorize the Breast Cancer Biopsy Images

Abstract

As macroscopic Breast Cancer (BC) imaging diagnostics do not provide satisfied data, microscopic image analysis is used to get optimum cell-nuclei segmentation for image categorization. The paper presents a Novel Hybrid Segmentation Method which uses the energy detail coefficients attained from Non-Subsampled Contourlet Transform for cell-nuclei segmentation of BC histopathological images. NHSM solves the local inhomogeneities problem while preserving all necessary details. The system evaluation is done using training dataset of 98 BC histopathological images and testing dataset of 26 images. Total of 25 segmented features was extracted for classification using Decision Trees, k-Nearest Neighbor, multilayer perceptron, Multiclass-Support Vector Machine (M-SVM). The proposed NHSM segmentation results were undergone through both subjective and objective performance evaluation. Result evaluation proved that NHSM along with Multi Class-Support Vector Machine classifier provides highly precise and accurate classified result for BC tissue images compared to state-of-the-art segmentation methods. Also, the edge detection model initialization is highly robust and insensitive.