Abstract

The determination of the basic drug Amperozide, one of its main metabolites, and a third related compound in human blood plasma is described. All three compounds include an amine functionality. The process is governed by a modified ASTED instrument (Gilson). The dialysis unit is exchanged for a supported liquid membrane (SLM), which gives a simultaneous cleanup and enrichment of the analytes. The ASTED is coupled to column liquid chromatographic equipment with UV detection

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