Abstract

The accurate quantitative analysis of dynamic image series for clinical evaluation of functional studies is investigated. The method, factor analysis of dynamic structures (FADS), simultaneously estimates in vivo spatial and temporal evolution of a tracer or a contrast agent from dynamic image series. FADS' main limitation occurs when the spatial structures are largely superimposed. A priori physiological information is introduced by means of a compartmental model to overcome this drawback. The theory is applied to early kinetics of /sup 99m/Tc HMDP in osseous tissues. >

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