Abstract

Obesity is a complex diseaseObjectiveEvaluate autologous subcutaneous adipose tissue (SAT) functionality as a therapeutic measure for obesity and its comorbidities.MethodsWe feed Wistar rats with a high‐carbohydrate (HC) or a high animal fat (HF) diet for 90 days. Glucose and triglyceride (TG) concentrations were evaluated each 30 days, oral glucose tolerance test (OGGT) at days 0, 90 and 180. On day 90 surgical procedures were performed randomly on all rats: 1) Sham (S) control, 2) autologous SAT transplant to visceral adipose tissue (T), 3) extraction (E) of SAT.ResultsOn day 180 OGGT showed lower insulin concentrations on T group with HF diet (p =0.002) in comparison to S, as well as a smaller increase in groups T and E on both diets (p=0.004) compared to S. The group with less weight gain was T with both diets. At day 180 TG concentrations were lower in groups E and T of both diets compared to group S. We measured cholesterol and TG in hepatic tissue, it was higher in S and E groups compared with T on HF diet (p=0.008). Rats that underwent autologous SAT transplantation showed a better response during OGGT and a smaller increase in weight compared to S group.ConclusionAutologous SAT transplantation to visceral compartment might be a useful clinical measure to improve carbohydrate metabolism and weight control.

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