Abstract
Copyright: © 2013 Brahimi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Autologous stem cell transplantation (ASCT) after a high dose conditioning is an established treatment modality with definitive indications for many haematological disorders.
Highlights
Autologous stem cell transplantation (ASCT) after a high dose conditioning is an established treatment modality with definitive indications for many haematological disorders
In 2007, Wannesson et al published a systematic review in which they demonstrated the feasibility and the safety of ASCT without cryopreservation of the graft [1]. They reviewed the methodologies and results of sixteen papers published from 1984 to 2006, on the subject of ASCT with noncryopreserved stem cells. 661 auto transplanted patients were reported in this reviewed literature, and two of them (0.32%) failed to engraftment
Wannesson et al concluded that ASCT with stem cell stored in the refrigerator at +4°C is a safe procedure as long as we use short regiment schedules [1]
Summary
Autologous Stem Cell Transplant with Non-Cryopreserved Grafts Autologous stem cell transplantation (ASCT) after a high dose conditioning is an established treatment modality with definitive indications for many haematological disorders. This line of treatment requires many expensive resources, such as freezing of the harvest product in order to maintain cell viability until stem-cell reinfusion.
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