Autologous Serum Skin Test for Initial Identification of Auto- Antibodies in Chronic Urticaria

Goutam Kumar Acherjya,Keya Tarafder,Mohammad Ali,Mohammad Moniruzzaman Khan,Mohammad Nura Alam,Muhammad Tanvir Mohith

doi:10.3329/jom.v19i2.37228

Abstract

Background: Autologous serum skin test (ASST) is easy to perform, cost effective measure for initial identification of auto-antibody in patients suffering from chronic urticaria which may occur due to autoimmune trigger by spontaneously developed auto-antibodies against FcμRI receptor of skin mast cells.Objective: This review is designed to see the positivity of ASST in patients suffering from chronic urticaria.Materials & Methods: This a retrospective data analysis conducted from the records of patients suffered from at least two episodes of urticaria or more in a week for 6 weeks and who did ASST aged more than 10 years between July 2015 to June 2017. These subjects were not pregnant or lactating mother, did not had urticarial vasculitis, predominant co-existing physical urticaria and had negative Hepatitis B antigen and anti-nuclear antibody reports.Results: Total 53 were included in this study of them 33 were female. Mean age was 32 years with a standard deviation (SD) of 11 years. Among study patients 16 (30.2% of total) had a positive ASST result. No age or sex difference was observed in positive ASST cases. In positive cases significant (p-value:<0.001) mean induration difference of 2.75mm with a SD of 1.00 mm observed than induration produced by negative control.Conclusion: ASST is easy and effective tool for initial identification of auto-reactive urticaria.J MEDICINE JUL 2018; 19 (2) : 100-103

Highlights

Urticaria is very common short-lived skin swellings due to transient leakage of plasma into the surrounding superficial dermis and its estimated lifetime prevalence is 20%.1 Release of numerous preformed chemotactic factors, enzymes, 1
No age or sex difference was observed in positive Autologous serum skin test (ASST) cases
Materials & Methods: This is a retrospective data analysis of records of patents aged more than 10 years attended in Dermatology outpatient services of Farazy Hoapital limited, Block-E, Banosree, Dhaka, Bangladesh between July 2015 to June 2017 with history of more than 6 weeks urticaria or suspected urticaria occurring at least twice a week who did the ASST

Summary

Introduction

Urticaria is very common short-lived skin swellings due to transient leakage of plasma into the surrounding superficial dermis and its estimated lifetime prevalence is 20%.1 Release of numerous preformed chemotactic factors, enzymes, 1. Urticaria is very common short-lived skin swellings due to transient leakage of plasma into the surrounding superficial dermis and its estimated lifetime prevalence is 20%.1. Release of numerous preformed chemotactic factors, enzymes, 1. 2. Assistant Professor, Haematology, National Institute of Cancer Research and Hospital, Mohakhali, Dhaka, Bangladesh. 3. Assistant Professor, Dermatology, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh. Jessore Medical College & Hospital, Jessore, Bangladesh. Autologous serum skin test (ASST) is easy to perform, cost effective measure for initial identification of auto-antibody in patients suffering from chronic urticaria which may occur due to autoimmune trigger by spontaneously developed auto-antibodies against FcμRI receptor of skin mast cells

Methods

Results

Discussion

Conclusion