Autologous Platelet-rich Plasma for the Treatment of Nonhealing Perineal Wounds: A Report of Two Cases

Abstract

Introduction. Patients with perineal wounds often encounter difficulty in local wound healing after hemorrhoidectomies. PRP contains a high concentration of platelets and has been used to improve wound healing. Objective. In this case study, PRP was used in the treatment of nonhealing perineal wounds to expedite wound healing. Case Reports. The 2 patients in these cases suffered from perineal wounds that were nonhealing for more than 2 months. After assessment of their physical condition, autologous PRP was used in the treatment of both patients. A total of 150 mL of peripheral blood was collected from each patient to prepare autologous PRP in a completely enclosed environment. For one patient, the PRP product was injected subcutaneously around the wound. The rest of the PRP product was activated into a gel by thrombin and calcium chloride, and the gel was applied to the surface of the wound with dressing changes every 5 days. The other patient was externally treated with autologous PRP gel, and dressing changes were administered after a week. The 2 patients were treated twice with PRP, and both completely recovered within 2 weeks without any other treatment. Conclusion. As an autologous blood-derived product, PRP was safe and showed promising results in perineal wound healing.