Abstract
BackgroundThe application of dental implants is often restricted by bone volume. In such cases, bone grafts are required, although bone graft materials have some disadvantages. Therefore, other effective approaches are needed. Our previous study showed that the autologous micrograft, a dissociated cell suspension made out of palatal connective tissue grafts, promoted bone-marrow cell proliferation and differentiation under osteogenic conditions. In this study, we aimed to evaluate the effects of dissociated soft-tissue suspensions relevant to bone regeneration in animal model.Material and methodsTwelve-week-old male Wistar rats were used in the study. Defects were created in rat calvaria, and were filled with hydrogel containing either dissociated soft-tissue suspension (test) or sucrose (control). The new bone formation was evaluated at 1 and 2 weeks after surgery (n = 16) by radiological and histological analysis.ResultsThe conducted radiological analysis showed that the new bone volume was significantly greater in the dissociated soft-tissue suspension group. This finding was further confirmed by the conducted histological analysis.ConclusionsThe dissociated mucosa tissue suspension enhanced bone regeneration in vivo; thus, it is a promising potential method to aid the successful application for bone augmentation in the implant practice.
Highlights
The application of dental implants is often restricted by bone volume
Autograft is considered one of the most reliable bone augmentation methods [7] because it can provide the grafting of both osteogenic cells and essential growth factors that are required for bone healing and remodeling [8]
The aim of this study was to evaluate the potential of dissociated soft-tissue suspension itself generated from palatal mucosa to enhance bone regeneration in rat calvarial bone graft model
Summary
The application of dental implants is often restricted by bone volume. In such cases, bone grafts are required, bone graft materials have some disadvantages. Previous studies have reported a significant increase in patient satisfaction with the function, comfort, and aesthetics of implant prosthesis compared with removable dentures [3, 4]. Autograft (i.e., autologous bone grafts) is considered one of the most reliable bone augmentation methods [7] because it can provide the grafting of both osteogenic cells and essential growth factors that are required for bone healing and remodeling [8]. Kawakami et al International Journal of Implant Dentistry (2021) 7:6 novel methods are urgently needed to facilitate effective and safe bone augmentation in the clinical situation
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