Abstract
Tissue engineering in hair regrowth aims to develop innovative and not-invasive procedures to advance the hair regrowth. A placebo-controlled, randomized, evaluator-blinded, half-head group study to compare hair regrowth with micrografts containing human hair follicle mesenchymal stem cells (HF-MSCs) vs. placebo was reported. After 58 weeks, 27 patients displayed in the targeted area an increase of hair count and hair density, respectively, of 18.0 hairs per 0.65 cm2 and 23.3 hairs per cm2 compared with baseline, while the control area displayed a mean decrease of 1.1 hairs per 0.65 cm2 and 0.7 hairs per cm2 (control vs. treatment: P < 0.0001). After 26 months, 6 patients revealed dynamic hair loss and were retreated. More broad controlled examinations are required. HF-MSCs contained in micrografts may represent a safe and viable treatment alternative against hair loss.
Highlights
For therapeutic hair regrowth, the use of micrografts containing autologous human hair follicle mesenchymal stem cells (HF-MSCs) has not been adequately considered
Long-Term Clinical and Trichoscopic Results. e results obtained displayed an improvement in the mean hair count (HC) at T5 after 58 weeks (58 weeks vs. 0 weeks) of 18.0 hairs in the targeted area (TA) (Figures 3(c) and 3(d)) compared with baseline (Figures 3(a) and 3(b)), while the control area (CA) displayed a mean decrease of 1.1 hairs
A mean increase in the total hair density (HD) of 23.3 hairs per cm2 (Figures 3(c) and 3(d)) compared with baseline (Figures 3(a), 3(b), 4(a), and 5(a)) was observed at T5 (Figures 4(d) and 5(b)), and the CA displayed a mean decrease of 0.7 hairs per cm2. ere were no statistically significant differences in vellus HD between the TA and the CA at T5
Summary
The use of micrografts containing autologous human hair follicle mesenchymal stem cells (HF-MSCs) has not been adequately considered. In AGA, the miniaturization of the follicles is determined by diminishment of anagen and with an improvement in the percentage of resting hair follicles (HFs), telogen, containing microscopic hairs in a hairless scalp [5]. Invading lymphocytes and mast cells have been seen around the miniaturizing follicle [6], detailed in the stem cell-rich lump zone [7]. Hair follicle stem cell numbers stay unaltered, though the number of more actively proliferating progenitor cells diminishes [8]. Is proposes going bald scalp either does not have an activator or has an inhibitor of hair follicle (HF) growth Hair follicle stem cell numbers stay unaltered, though the number of more actively proliferating progenitor cells diminishes [8]. is proposes going bald scalp either does not have an activator or has an inhibitor of hair follicle (HF) growth
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