Year-end Sale % OFF 
Abstract
The regenerative potential of brain has led to emerging therapies that can cure clinico-motor deficits after neurological diseases. Bone marrow mononuclear cell therapy is a great hope to mankind as these cells are feasible, multipotent and aid in neurofunctional gains in Stroke patients. This study evaluates safety, feasibility and efficacy of autologous mononuclear (MNC) stem cell transplantation in patients with chronic ischemic stroke (CIS) using clinical scores and functional imaging (fMRI and DTI). Non randomised controlled observational study Study: Twenty four (n=24) CIS patients were recruited with the inclusion criteria as: 3 months-2years of stroke onset, hand muscle power (MRC grade) at least 2; Brunnstrom stage of recovery: II-IV; NIHSS of 4-15, comprehendible. Fugl Meyer, modified Barthel Index (mBI) and functional imaging parameters were used for assessment at baseline, 8 weeks and at 24 weeks. Twelve patients were administered with mean 54.6 million cells intravenously followed by 8 weeks of physiotherapy. Twelve patients served as controls. All patients were followed up at 24 weeks. The laboratory and radiological outcome measures were within normal limits in MNC group. Only mBI showed statistically significant improvement at 24 weeks (p<0.05) whereas the mean FM, MRC, Ashworth tone scores in the MNC group were high as compared to control group. There was an increased number of cluster activation of Brodmann areas BA 4, BA 6 post stem cell infusion compared to controls indicating neural plasticity. Cell therapy is safe and feasible which may facilitate restoration of function in CIS.
Highlights
The frightening incidence of stroke in society has fuelled interest in regenerative medicine to repair brain after an acute insult or restore maximum functionality in the shortest possible time. [1] It is a well known fact that more than half of stroke survivors are dependent on care givers. [2] These findings have led the researchers to develop newer therapies and cell transplantation is one such hope which holds a great promise
Six clinical trials and one case report have been published [3] with stem cell therapy in ischemic and hemorrhagic stroke. [4,5,6,7] Embryonic, fetal neural, immortalised cell lines, human umbilical cord blood and bone marrow derived cells have been exploited in stroke, aiding in recovery through secretion of neurotrophic factors, promoting endogenous repair and preventing apoptosis. [8]
It has been postulated in rat models and clinical trials that bone marrow mononuclear stem cells are capable of neurogenesis and angiogenesis modulating the ‘host environment’
Summary
The frightening incidence of stroke in society has fuelled interest in regenerative medicine to repair brain after an acute insult or restore maximum functionality in the shortest possible time. [1] It is a well known fact that more than half of stroke survivors are dependent on care givers. [2] These findings have led the researchers to develop newer therapies and cell transplantation is one such hope which holds a great promise. Six clinical trials and one case report have been published [3] with stem cell therapy in ischemic and hemorrhagic stroke. A number of clinical trials are currently underway investigating the role of bone-marrow-derived mononuclear stem cell therapy at different stages of ischemic stroke and utilising different methods of delivery but the results of same are awaited. Bone marrow mononuclear cell therapy is a great hope to mankind as these cells are feasible, multipotent and aid in neurofunctional gains in Stroke patients. Aims: This study evaluates safety, feasibility and efficacy of autologous mononuclear (MNC) stem cell transplantation in patients with chronic ischemic stroke (CIS) using clinical scores and functional imaging (fMRI and DTI). Cell therapy is safe and feasible which may facilitate restoration of function in CIS
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
