Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases

Abstract

Autoimmune diseases are an important field for the development of hematopoietic stem cell transplantation (HSCT). The Brazilian Society for Cellular Therapy and Bone Marrow Transplantation (Sociedade Brasileira de Terapia Celular e Transplante de Medula Óssea, SBTMO) organized consensus meetings for the Autoimmune Diseases Group, to review the available literature on HSCT for autoimmune diseases, aiming to gather data that support the procedure for these patients. Three autoimmune diseases for which there are evidence-based indications for HSCT are multiple sclerosis, systemic sclerosis and Crohn’s disease. The professional stem cell transplant societies in North America (ASTCT), Europe (EBMT) and Brazil (SBTMO) currently consider HSCT as a therapeutic modality for these three autoimmune diseases. The data are here updated.