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Abstract
Autologous chondrocyte implantation (ACI) has been performed in more than 4,500 patients and, when appropriately indicated, provides durable hyaline-like repair tissue with consistent clinical results. ACI is primarily indicated for full-thickness articular cartilage injuries of the femoral condyles and trochlea. Emerging evidence suggests that it may also have a role in the treatment of patellar defects. The success of ACI is in part attributed to its ability to resolve the limitations of other techniques that are at best palliative or reparative with limited capacity to restore hyaline or hyaline-like tissue. Lesions of the femoral condyles and trochlea can be expected to respond favorably to treatment in greater than 85% of all patients, both clinically and subjectively with follow-up at 2 to 9 years. Patients with multiple lesions or lesions involving the patella have not responded as well, but up to 70% still show improvement with more consistent results if ACI is accompanied by a patellar realignment procedure when indicated.
Published Version
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