Autologous and allogeneic transplantation for aggressive T-cell lymphomas: A single institution experience

Abstract

8558 Aggressive T-cell lymphomas (ATCL) represent 10–15% of non-Hodgkin lymphoma and have a worse prognosis than aggressive B-cell lymphomas. Both autologous (Auto) and allogeneic (Allo) stem cell transplantation have been used as consolidation in first remission and at relapse, but the role of transplantation has not been clearly defined. There were 24 Auto and 18 Allo between 8/1997 and 12/2007. The Allo group consisted of 4 PTCLu, 3 angioimmunoblastic(AITL), 2 panniculitis-like, 2 cutaneous(CTCL) with large cell transformation, 2 NK-cell, 2 anaplastic large cell(ALCL), 1 hepatosplenic, 1 enteropathic, and 1 refractory CTCL. The Auto group consisted of 6 PTCLu, 12 ALCL (5 Alk+, 5 Alk-, 2 Alk unk), 4 AITL, 1 CTCL with transformation, and 1 T-lymphoblastic lymphoma. The median age was 51y(Allo) and 52y(Auto). Median prior therapies were 3(Allo) and 1(Auto). There were 14 matched- and 4 matched-unrelated Allo transplants; 7 were ablative and 11 were reduced-intensity. Median time from diagnosis to Allo or Auto was 18 and 8mo, respectively. Median follow-up was 29mo (Allo) and 24mo (Auto). The day 100 TRM was 11%(Allo) and 4%(Auto) respectively. The relapse mortality was 11%(Allo) and 33%(Auto). The non-relapse mortality was 33%(Allo) and 8%(Auto). The 1- and 2-year overall survival(OS) rates were similar within the Allo and Auto groups (78% vs 74%, and 67% vs 60% respectively). The 1- and 2-year progression-free survival (PFS) for the Allo vs Auto groups were 68% vs 52%, and 53% vs 45%, respectively (p=0.28). Within the Auto group, 14(58%) were transplanted in first complete remission(CR1), and 10(42%) in CR2, beyond CR2, or PR. Patients in CR1 had significantly better PFS (57 vs 17mo, p=0.007) and OS (76 vs 29mo, p=0.004) than those in CR2, beyond CR2, or PR. Allo patients with prior Auto(6) had a poorer OS than patients with no prior Auto(12), 32 vs 60mo, respectively, but the results were not statistically significant, p=0.15. One Allo was transplanted in CR1 and is still alive at 33mo. We conclude that outcomes for Auto are best in CR1. For patients with resistant or relapsed disease, Allo should be strongly considered rather than Auto. These results also suggest that a prospective randomized trial comparing Auto and Allo for ATCL in first remission is warranted. No significant financial relationships to disclose.