Abstract
Immunology Both the adaptor protein CARD9 and loss of the kinase Lyn are associated with autoimmune disease, notably colitis and inflammatory bowel disease. Ma et al. found in mice that CARD9 amplified Toll-like receptor signaling and cytokine production in Lyn-deficient dendritic cells but not macrophages. Deleting the Card9 gene or genes encoding Src-family kinases in dendritic cells prevented the development of Lyn deficiency–associated colitis in mice. Targeting CARD9 or its associated kinases may be a way to relieve inflammation in patients with autoimmune disease. Sci. Signal. 12 , eaao3829 (2019).
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