Abstract
Angel Alberto Justiz Vaillant1*, Wayne Mohammed1, Sehlule Vuma1 and Norma Anderson2 1Department of Para-clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, West Indies 2Department of Basic Medical Sciences, The University of the West Indies, Mona campus, Jamaica, West Indies *Corresponding author: Angel Alberto Justiz Vaillant, Department of Para-clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago, West Indies, E-mail: avail4883@gmail.com
Highlights
Letter to the EditorGlutamatergic function deficits are hypothesized to contribute to the pathogenesis of neuropsychiatric disorders, including schizophrenia
Autoimmunity in Neurological and Psychiatric Disorders: Participation of Antibodies and Cytokines in the Immunopathogenesis of these Diseases
In autoimmune encephalitis is thought that the receptors and proteins involved in glutamatergic neurotransmission are the antigen targets: N-methyl-d-aspartate (NMDA) and alphaamino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA) receptors [1]
Summary
Glutamatergic function deficits are hypothesized to contribute to the pathogenesis of neuropsychiatric disorders, including schizophrenia. Autoantibodies (Ab's) to the "B" peptide (amino acids 372-395) of glutamate/AMPA receptor subtype 3 (GluR3) were found in serum and cerebrospinal fluid of some patients with different types of epilepsy but not association was found between the presence of such antibodies and patients suffering from epilepsy that accompanies anti-phospholipid syndrome (APS) or Sneddon's syndrome (SNS), which are two autoimmune disorders [4] Anyway these findings are important because some of these neurological disorders may fall in the field of clinical immunology and it may be needed the realization of a screening for specific autoimmune antibodies and immune cells, complement proteins and cytokines.
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