Abstract
Abstract Sera from 171 cases of patients with various kinds of liver disease were studied with autoimmune complement fixation and hemagglutination methods in order to detect liver autoantibodies. Liver autoantibodies were found in almost all sera from active cases of primary biliary cirrhosis, postnecrotic cirrhosis, plasma cell hepatitis, lupoid hepatitis, drug-induced jaundice, and in some cases of systemic lupus erythematosus. Antibodies were rarely encountered in acute infectious hepatitis but appeared more frequently in prolonged cases. The autoantibodies of postnecrotic cirrhosis appear to be distinct from those of primary biliary cirrhosis on the basis of reaction to different liver antigens. Most of the antigenic components of the liver appear to be insoluble in normal saline. In cases of Laennec's cirrhosis, extrahepatic obstructive jaundice, neoplasm of the liver, and in 132 blood bank donors, the blood serum did not exhibit circulating autoantibodies against liver antigens of any type. Rough correlation was observed between the height of antibody titer, the γ-globulin level, and the severity of manifestations. Approximately half of the cases of liver disease had anticomplementary sera as opposed to one sixth in the control series.
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