Abstract
IntroductionGraves' disease and myasthenia gravis are both auto-immune diseases and the coexistence of these two diseases is rare but well recognized. Myasthenia gravis is more frequent in patients with thyroid disease.Case presentationHere we present a case of 28-year-old male patient having Auto-immune thyroid disease (Graves' disease) with concomitant myasthenia gravis.ConclusionIn conclusion, we report that the coexistence of Myasthenia Gravis with Autoimmune thyroid disease might have prognostic relevance and occurs in a subgroup of myasthenia gravis patients with a mild form of the disease.
Highlights
Graves’ disease and myasthenia gravis are both auto-immune diseases and the coexistence of these two diseases is rare but well recognized
Myasthenia gravis is more frequent in patients with thyroid disease
Case presentation: Here we present a case of 28-year-old male patient having Auto-immune thyroid disease (Graves’ disease) with concomitant myasthenia gravis
Summary
Robert Graves’ disease, first described by Parry in 1825 [1], is best known as Graves’ disease and is characterized by diffuse goiter (Thyrotoxicosis), infiltrative orbitopathy & ophthalmopathy and occasionally infiltrative dermopathy. Graves’ disease, is characterized by a non-homogeneous lymphocytic (T-cells: Th1 and Th2 types along with CD25+ regulatory T cells; while B-cell germinal centers are much less common) infiltration with an absence of follicular destruction [4]. Case presentation A 28-year-old Indian male, with Indoaryan ethnicity nonsmoker, non-alcoholic patient, laborer by occupation presented to hospital with a history of gradually increasing painful swelling in the neck of 3 months duration associated with difficulty in swallowing and palpitations. It was not associated with hoarseness of voice, difficulty in breathing. In addition to Neomercazole 10 mg three times daily, Pyridostigmine 30 mg three times daily was added for the treatment of ptosis and increased to 60 mg t.i.d., with patient showing dramatic improvement both in symptoms and signs after the start of therapy
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