Abstract
The pathogenesis of sporadic inclusion body myositis (sIBM) is unclear. Two main hypotheses correspond to the main components of the disorder's pathology: initiation by inflammation versus primarily degenerative process. These ideas are based on (i) an autoimmune attack against muscle fibres with infiltrates, invasion of non-necrotic fibres as well as frequent autoantibodies and (ii) disturbed autophagy and pathological protein aggregation in the general absence of a meaningful clinical response to immunosuppressive therapies.
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