Abstract
Peripheral blood smear for patients with CLL and AIHA usually shows lymphoid cells with scant cytoplasm and small round nuclei with condensed chromatin, smudge cells and spherocytes.
Highlights
AL HADIDI and UDDEN development of autoimmune hemolytic anemia (AIHA) in 4% of patients with chronic lymphocytic leukemia (CLL).[2]
A 60-year-old male patient admitted to the hospital with fever, nausea, vomiting, and watery diarrhea of three days. He was diagnosed with chronic lymphocytic leukemia (CLL) 14 years prior to presentation and was treated previously with FCR, and most recently on Ibrutinib
He was diagnosed with idiopathic thrombocytopenic purpura (ITP) for which he is on eltrombopag
Summary
AL HADIDI and UDDEN development of AIHA in 4% of patients with CLL.[2]. DAT can be negative in patients with CLL presenting with AIHA. Peripheral blood smear for patients with CLL and AIHA usually shows lymphoid cells with scant cytoplasm and small round nuclei with condensed chromatin, smudge cells and spherocytes. KEYWORDS autoimmune hemolytic anemia, chronic lymphocytic leukemia, peripheral blood smear, spherocytes
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