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Abstract
Autoimmune Diseases (ADs) are diseases in which the immune system mistakenly attacks and destroys selfmolecules due to a disruption of immunologic tolerance to auto-reactive immune cells. The goals of treatments for ADs are to 1) reduce symptoms, 2) control the autoimmune process and 3) maintain the body’s ability to fight disease. Allogenic Hematopoietic Stem Cell (HSC) transplantation has been shown to be a relatively successful treatment for experimental ADs. Intra Bone Marrow-Bone Marrow Transplantation (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hemopoietic recovery and the complete restoration of T cell functions even in donor-recipient combinations across MHC barriers. In this review, we summarize the ADs treatable with IBM-BMT.
Highlights
Autoimmune Diseases (ADs) represent a heterogeneous group of disorders with genetic, environmental and individual etiological factors [1]
Allogenic Hematopoietic Stem Cell (HSC) transplantation has been shown to be a relatively successful treatment for experimental ADs, and there are a number of reports of Bone Marrow Transplantation (BMT) being used to treat ADs in various mice [3,4,5,6,7,8,9,10]
The following were all resolved after BMT: Insulin-Dependent Diabetes Mellitus (IDDM), in which beta cells are destroyed by the immune system; Rheumatoid arthritis (RA), which primarily attacks the synovial joints; Systemic Lupus Erythematosus (SLE), which is a chronic auto-inflammatory disease of unknown etiology; Multiple Sclerosis (MS), which affects the brain and the central nervous system, and Autoimmune Pancreatitis (AIP), which produces pancreatic masses and ductal strictures [11,12]
Summary
Autoimmune Diseases (ADs) represent a heterogeneous group of disorders with genetic, environmental and individual etiological factors [1]. The following were all resolved after BMT: Insulin-Dependent Diabetes Mellitus (IDDM), in which beta cells are destroyed by the immune system; Rheumatoid arthritis (RA), which primarily attacks the synovial joints; Systemic Lupus Erythematosus (SLE), which is a chronic auto-inflammatory disease of unknown etiology; Multiple Sclerosis (MS), which affects the brain and the central nervous system, and Autoimmune Pancreatitis (AIP), which produces pancreatic masses and ductal strictures [11,12]. Systemic autoimmune disorders often affect joints they may affect the skin, kidneys, heart, lungs and red blood cells. They include SLE, Sjögren’s syndrome, scleroderma, rheumatoid arthritis, and dermatomyositis. Our previous report indicated that both systemic and organ-specific ADs could be prevented by BMT [16]
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