Abstract
Autoimmune Disease Genetics
Highlights
Given this background, we have assembled this special issue with a goal of highlighting important progress in a diverse range of topics in human autoimmune disease
Carvalheiro et al in the paper “Tolerogenic versus inflammatory activity of peripheral blood monocytes and dendritic cells subpopulations in systemic lupus erythematosus” explore the human immune system and find a decrease in tolerogenic dendritic cells in systemic lupus erythematosus, a disease in which dendritic cells play an important role in pathogenesis [5]
Koldobskaya et al use a novel eQTL technique to prioritize additional candidate gene loci from a prior genome-wide screen of systemic lupus erythematosus, supporting the idea that we can increase the yield of our genetic screens when we can apply our knowledge of disease biology in candidate selection in the paper “Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus.”
Summary
We have assembled this special issue with a goal of highlighting important progress in a diverse range of topics in human autoimmune disease.
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