Abstract
The first major finding that allowed us to progress in our understanding of autoimmune blistering skin diseases was that chronic blistering diseases of the skin could be differentiated. The initial major clinical differentiation was between pemphigus and pemphigoid and, still today, our major progress in understanding these diseases comes from patients with pemphigus and pemphigoid. Therefore, in this review of historical perspectives, we will focus on pemphigus and pemphigoid. The early history and the clinical and histological differentiation of pemphigus, pemphigoid, and related diseases is beautifully described in a classic monograph by a giant in the field, Walter Lever (1965). Although many contributed to the differentiation at the histological and clinical level, Walter Lever, informed by his own patients and their histology, was a major figure in synthesizing and distilling the essence of this information.
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