Abstract
Investigators at the French Reference Center on Paraneoplastic Neurological Syndrome (PNS), Lyon Neuroscience Research Center, and other centers in France performed a retrospective study of children and adolescents with anti-Hu antibodies (Hu-Abs) collected by the Reference Center between Jan 1, 2000 and Dec 31, 2011.
Highlights
Investigators at the French Reference Center on Paraneoplastic Neurological Syndrome (PNS), Lyon Neuroscience Research Center, and other centers in France performed a retrospective study of children and adolescents with anti-Hu antibodies (HuAbs) collected by the Reference Center between Jan 1, 2000 and Dec 31, 2011
All of the 243 adult patients with Hu-Abs had PNS whereas only 2 of 8 (25%) children had neuroblastoma and opsoclonusmyoclonus
The majority (6 children; 5 female, 1 male) presented with limbic encephalitis manifested by progressive personality changes, memory loss, and seizure, and were free of cancer at a mean follow-up of 50 months
Summary
Investigators at the French Reference Center on Paraneoplastic Neurological Syndrome (PNS), Lyon Neuroscience Research Center, and other centers in France performed a retrospective study of children and adolescents with anti-Hu antibodies (HuAbs) collected by the Reference Center between Jan 1, 2000 and Dec 31, 2011. Of 251 patients with Hu-Abs, 8 were younger than 18 years.
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