Abstract
Currently, in medical practice, there is a high interest in diseases caused by herpes viruses, among them the Epstein-Barr virus (EBV) occupies the leading place. Almost 90% of the worlds population over the age of 40 are infected with VEB. In patients of the first two years, the proportion of asymptomatic carriage reaches 90%, and at the age of 2-10 30-50%. The article considers current data on the impact of EBV on cellular and humoral immunity, its connection with autoimmune and lymphoproliferative diseases. EBV has been shown to play a significant role in the onset of oncological diseases such as Hodgkins lymphoma, Burkitts lymphoma, nasopharyngeal carcinomas, as well as autoimmune diseases systemic lupus erythematosus, rheumatoid arthritis, Sjogrenʼs syndrome, autoimmune hepatitis, lymphoid interstitial hepatitis, lymphoid interstitial syndrome. The results of studies over the past 5 years of cases of activation of autoimmune processes associated with EBV infection, as well as predisposing factors underlying these manifestations, are presented. Due to the fact that the autoimmune effect of EBV infection is manifested in various organs and tissues, this problem is multidisciplinary, affecting such fields of medicine as pediatrics, infectious diseases, endocrinology, oncology, gynecology, ophthalmology, gastroenterology, etc.
Highlights
В настоящее время в медицинской практике сохраняется высокий интерес к заболеваниям, вызванным герпесвирусами, среди которых лидирующее место занимает вирус Эпштейна – Барр (ВЭБ)
In medical practice, there is a high interest in diseases caused by herpes viruses, among them the Epstein-Barr virus (EBV) occupies the leading place
EBV has been shown to play a significant role in the onset of oncological diseases such as Hodgkin’s lymphoma, Burkitt’s lymphoma, nasopharyngeal carcinomas, as well as autoimmune diseases – systemic lupus erythematosus, rheumatoid arthritis, Sjogrens syndrome, autoimmune hepatitis, lymphoid interstitial hepatitis, lymphoid interstitial syndrome
Summary
В настоящее время в медицинской практике сохраняется высокий интерес к заболеваниям, вызванным герпесвирусами, среди которых лидирующее место занимает вирус Эпштейна – Барр (ВЭБ). Что ВЭБ играет значительную роль в возникновении онкологических заболеваний, таких как лимфома Ходжкина, лимфома Беркитта, назофарингеальная карцинома, а также аутоиммунных заболеваний — системной красной волчанки, ревматоидного артрита, синдрома Шегрена, аутоиммунного гепатита, лимфоидного интерстициального пневмонита. Autoimmune and lymphoproliferative malignant diseases associated with Epstein-Barr viral infection
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